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Bioactive Sutures: A Review of the Advances in Surgical Sutures Functionalization

Song, W; Alshomer, F; Madhavan, A; Pathan, O; (2017) Bioactive Sutures: A Review of the Advances in Surgical Sutures Functionalization. Current Medicinal Chemistry , 24 (2) 10.2174/0929867324666161118141724. Green open access

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Abstract

Sutures have been at the forefront of surgical medicine throughout time. With recent advances in suture technology, it is possible to incorporate biologically active substances to enhance suture function and capability. Bioactive sutures represent a modality interest in controlled drug and cell delivery to traumatic sites. In this article, a comprehensive literature search of key bibliographic databases focusing on suture material fabrication and advanced modification was performed. The history, manufacturing process and cost-effectiveness of bioactive sutures are presented. Several novel modifications to enhance function in drug and growth factor delivery and cell therapy are also reviewed. Different antimicrobial drugs and anaesthetics have been shown to be effective in reducing inflammation and bacterial infection. Cellular therapy represents a unique modality augmenting the surgical repair of various soft tissue injuries. We propose a definition of bio-active sutures as biomaterials that are engineered to have controlled tissue interaction to optimise wound/defect healing, in addition to their essential function in tissue approximation.

Type: Article
Title: Bioactive Sutures: A Review of the Advances in Surgical Sutures Functionalization
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/0929867324666161118141724
Publisher version: http://dx.doi.org/10.2174/092986732466616111814172...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Surgery; Sutures; Wounds; Biomaterial; Bio-functionalization; ActivationSurgery; Sutures; Wounds; Biomaterial; Bio-functionalization; Activation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1529460
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