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Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin

Liu, TH; Tang, YJ; Huang, Y; Wang, L; Guo, XL; Mi, JQ; Liu, LG; ... Hong, DL; + view all (2017) Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin. Leukemia , 31 (5) pp. 1079-1086. 10.1038/leu.2016.313. Green open access

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Abstract

The origin of cancers is associated with etiology as well as therapeutics. Several studies reveal that malignancies in children can originate in utero. However a diagnostic approach to distinguish between cancers initiated pre- or postnatally is absent. Here we identified a transcriptional factor FEV that was expressed in fetal hematopoietic cells and became silent after birth. We characterized that FEV was essential for the self-renewal of hematopoietic stem cells (HSCs). We next found FEV was expressed in most infant leukemia samples, but not in adult samples, in accord with the known pre-natal origins of the former. We further determined the majority of pediatric acute lymphoid and myeloid leukemias (ALL and AML) were FEV-positive. Moreover FEV-knockdown markedly impaired the leukemia-propagating ability of leukemic stem cells. We therefore identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin. It may also provide a tractable therapeutic target.Leukemia accepted article preview online, 03 November 2016. doi:10.1038/leu.2016.313.

Type: Article
Title: Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/leu.2016.313
Publisher version: http://doi.org/10.1038/leu.2016.313
Language: English
Additional information: © 2016 Macmillan Publishers Limited. All rights reserved.. This is an unedited manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/1529355
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