Naghynajadfard, M;
(2016)
Mouse xenograft model of corticospinal tract by delayed transplantation of olfactory ensheating cells in adult rats.
Masters thesis , UCL (University College London).
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Abstract
Adult rats were trained to use their forepaw for retrieving a piece of noodle through a slit in the front of the cage. The dorsal corticospinal tract was lesioned by a focal stereotactic radio-frequency lesion at the level of the first/second cervical segment. Complete destruction of one side of the corticospinal tract completely prevented the use of the ipsilateral forepaw reaching for at least 6 months after operation. Rats which have shown no forepaw retrieval by 8 weeks were xenotransplanted with a suspension of cultured olfactory ensheathing cells derived from the mouse olfactory bulb, into the lesion site. Starting between 1 and 3 weeks, 10 rats with transplants bridging the lesion site resumed ipsilateral forepaw reaching.The histology of the lesioned rats with misplaced olfactory ensheathing cell showed no functional recovery during the 8 weeks of training.
| Type: | Thesis (Masters) |
|---|---|
| Title: | Mouse xenograft model of corticospinal tract by delayed transplantation of olfactory ensheating cells in adult rats |
| Event: | UCL (University College London) |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1528636 |
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