Rogerson, C;
Gissen, P;
(2016)
The CHEVI tethering complex: facilitating special deliveries.
Journal of Pathology
, 240
(3)
pp. 249-252.
10.1002/path.4785.
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Abstract
VPS33B and VIPAR comprise the two known components of the recently christened class C Homologues in Endosome–Vesicle Interaction (CHEVI) complex, thought to act as a tethering complex in endosomal trafficking distinct from the HOPS and CORVET complexes in mammalian cells. A recent paper in The Journal of Pathology further explores the role of the CHEVI complex in the biogenesis of α-granules in megakaryocytes, identifying two novel interactors of this complex: α-tubulin and SEC22B, and demonstrating that VPS33B expression is required for the localization of SEC22B and the α-granule cargo VWF to proplatelets in megakaryocytes. These findings advance the current knowledge of the function of the CHEVI complex in α-granule biogenesis and together with studies in other systems, corroborate its role in the specialized delivery of cargo in different cell types.
| Type: | Article |
|---|---|
| Title: | The CHEVI tethering complex: facilitating special deliveries |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/path.4785 |
| Publisher version: | http://doi.org/10.1002/path.4785 |
| Language: | English |
| Additional information: | Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. All rights reserved. This is the peer reviewed version of the following article: Rogerson, C; Gissen, P; (2016) The CHEVI tethering complex: facilitating special deliveries. Journal of Pathology , 240 (3) pp. 249-252, which has been published in final form at http://doi.org/10.1002/path.4785. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, Pathology, Vps33b, Vipar, Vesicle Trafficking, Tethering Complexes, Megakaryocyte, Platelet, -granules, Chevi Complex, Renal Dysfunction, Mammalian Corvet, Hops, Arthrogryposis, Trafficking, Maturation, Fusion, Megakaryocytes, Recruitment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1528326 |
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