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The CHEVI tethering complex: facilitating special deliveries

Rogerson, C; Gissen, P; (2016) The CHEVI tethering complex: facilitating special deliveries. Journal of Pathology , 240 (3) pp. 249-252. 10.1002/path.4785. Green open access

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Abstract

VPS33B and VIPAR comprise the two known components of the recently christened class C Homologues in Endosome–Vesicle Interaction (CHEVI) complex, thought to act as a tethering complex in endosomal trafficking distinct from the HOPS and CORVET complexes in mammalian cells. A recent paper in The Journal of Pathology further explores the role of the CHEVI complex in the biogenesis of α-granules in megakaryocytes, identifying two novel interactors of this complex: α-tubulin and SEC22B, and demonstrating that VPS33B expression is required for the localization of SEC22B and the α-granule cargo VWF to proplatelets in megakaryocytes. These findings advance the current knowledge of the function of the CHEVI complex in α-granule biogenesis and together with studies in other systems, corroborate its role in the specialized delivery of cargo in different cell types.

Type: Article
Title: The CHEVI tethering complex: facilitating special deliveries
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/path.4785
Publisher version: http://doi.org/10.1002/path.4785
Language: English
Additional information: Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. All rights reserved. This is the peer reviewed version of the following article: Rogerson, C; Gissen, P; (2016) The CHEVI tethering complex: facilitating special deliveries. Journal of Pathology , 240 (3) pp. 249-252, which has been published in final form at http://doi.org/10.1002/path.4785. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Pathology, Vps33b, Vipar, Vesicle Trafficking, Tethering Complexes, Megakaryocyte, Platelet, -granules, Chevi Complex, Renal Dysfunction, Mammalian Corvet, Hops, Arthrogryposis, Trafficking, Maturation, Fusion, Megakaryocytes, Recruitment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1528326
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