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Rho GTPases in mammalian spinal neural tube closure

Rolo, A; Escuin, S; Greene, ND; Copp, AJ; (2018) Rho GTPases in mammalian spinal neural tube closure. Small GTPases , 9 (4) pp. 283-289. 10.1080/21541248.2016.1235388. Green open access

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Abstract

Neural tube closure is an important morphogenetic event that involves dramatic reshaping of both neural and non-neural tissues. Rho GTPases are key cytoskeletal regulators involved in cell motility and in several developmental processes, and are thus expected to play pivotal roles in neurulation. Here, we discuss 2 recent studies that shed light on the roles of distinct Rho GTPases in different tissues during neurulation. RhoA plays an essential role in regulating actomyosin dynamics in the neural epithelium of the elevating neural folds, while Rac1 is required for the formation of cell protrusions in the non-neural surface ectoderm during neural fold fusion.

Type: Article
Title: Rho GTPases in mammalian spinal neural tube closure
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/21541248.2016.1235388
Publisher version: http://dx.doi.org/10.1080/21541248.2016.1235388
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Cdc42, Rac1, RhoA, actomyosin, cell protrusions, morphogenesis, mouse, neurulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1527218
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