Horvat, P;
Kubinova, R;
Pajak, A;
Tamosiunas, A;
Schöttker, B;
Pikhart, H;
Peasey, A;
... Bobak, M; + view all
(2016)
Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.
Dementia amd Geriatric Cognitive Disorders
, 42
(5-6)
pp. 297-309.
10.1159/000450702.
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Abstract
BACKGROUND/AIMS: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. METHODS: Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores cross-sectionally (n = 4,304) and prospectively (n = 2,882). RESULTS: Increased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function. CONCLUSION: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.
| Type: | Article |
|---|---|
| Title: | Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study. |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1159/000450702 |
| Publisher version: | http://dx.doi.org/10.1159/000450702 |
| Language: | English |
| Additional information: | © 2016 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY) (http://www.karger.com/Services/OpenAccessLicense). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher. |
| Keywords: | Oxidative stress, Free radicals, Aging, Cognitive function, Cohort studies, Epidemiology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1527134 |
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