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Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.

Horvat, P; Kubinova, R; Pajak, A; Tamosiunas, A; Schöttker, B; Pikhart, H; Peasey, A; ... Bobak, M; + view all (2016) Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study. Dementia amd Geriatric Cognitive Disorders , 42 (5-6) pp. 297-309. 10.1159/000450702. Green open access

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Abstract

BACKGROUND/AIMS: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. METHODS: Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores cross-sectionally (n = 4,304) and prospectively (n = 2,882). RESULTS: Increased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function. CONCLUSION: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.

Type: Article
Title: Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000450702
Publisher version: http://dx.doi.org/10.1159/000450702
Language: English
Additional information: © 2016 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY) (http://www.karger.com/Services/OpenAccessLicense). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher.
Keywords: Oxidative stress, Free radicals, Aging, Cognitive function, Cohort studies, Epidemiology
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1527134
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