Shmueli, K;
Kawadler, J;
Carmichael, D;
Clark, CA;
Kirkham, FJ;
(2015)
Susceptibility Mapping in Sickle Cell Anaemia Patients with and Without Chronic Blood Transfusions.
In:
Proc. Intl. Soc. Mag. Reson. Med. 23 (2015).
ISMRM
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Abstract
Sickle cell anaemia (SCA) is a genetic disorder affecting haemoglobin. Previous studies suggest that the iron content in some deep-brain regions is higher in transfused SCA patients (TSCA) than in healthy controls (HC). We hypothesised that iron content in those regions is lower in non-transfused patients (NSCA) than in controls as NSCA have low haematocrit. A pilot study (5 TSCA, 5 NSCA, 5 HC) showed that susceptibility values were significantly lower in the globus pallidus of both TSCA and NSCA than in HC, supporting our second hypothesis. A larger study (20 NSCA, 18 HC) showed a trend in this direction.
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