UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Susceptibility Mapping in Sickle Cell Anaemia Patients with and Without Chronic Blood Transfusions

Shmueli, K; Kawadler, J; Carmichael, D; Clark, CA; Kirkham, FJ; (2015) Susceptibility Mapping in Sickle Cell Anaemia Patients with and Without Chronic Blood Transfusions. In: Proc. Intl. Soc. Mag. Reson. Med. 23 (2015). ISMRM Green open access

[thumbnail of Shmueli__Shmueli_2015_Susceptibility Mapping in Sickle Cell Anaemia Patients with and Without Chronic Blood Transfusions_Proc_ISMRM_23_0286.pdf]
Preview
Text
Shmueli__Shmueli_2015_Susceptibility Mapping in Sickle Cell Anaemia Patients with and Without Chronic Blood Transfusions_Proc_ISMRM_23_0286.pdf - Accepted Version

Download (669kB) | Preview

Abstract

Sickle cell anaemia (SCA) is a genetic disorder affecting haemoglobin. Previous studies suggest that the iron content in some deep-brain regions is higher in transfused SCA patients (TSCA) than in healthy controls (HC). We hypothesised that iron content in those regions is lower in non-transfused patients (NSCA) than in controls as NSCA have low haematocrit. A pilot study (5 TSCA, 5 NSCA, 5 HC) showed that susceptibility values were significantly lower in the globus pallidus of both TSCA and NSCA than in HC, supporting our second hypothesis. A larger study (20 NSCA, 18 HC) showed a trend in this direction.

Type: Proceedings paper
Title: Susceptibility Mapping in Sickle Cell Anaemia Patients with and Without Chronic Blood Transfusions
Event: 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine
Location: Toronto, Ontario, Canada
Dates: 30 May 2015 - 05 June 2015
Open access status: An open access version is available from UCL Discovery
Publisher version: http://dev.ismrm.org/2015/0286.html
Language: English
Additional information: Copyright © 2015 ISMRM, All Rights Reserved.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1526962
Downloads since deposit
28Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item