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Punctate Inner Choroidopathy: A Review

Ahnood, D; Madhusudhan, S; Tsaloumas, MD; Waheed, NK; Keane, PA; Denniston, AK; (2016) Punctate Inner Choroidopathy: A Review. Survey of Ophthalmology , 62 (2) pp. 113-126. 10.1016/j.survophthal.2016.10.003. Green open access

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Abstract

Punctate Inner Choroidopathy (PIC), an idiopathic inflammatory multifocal chorioretinopathy that predominantly affects young myopic women, appears to be relatively rare, but there is limited data to support accurate estimates of prevalence, and it is likely that the condition is under-diagnosed. The etiological relationship between PIC and other conditions within the 'white dot syndromes' group remains uncertain. We, like others, would suggest that PIC and multifocal choroiditis with panuveitis (MCP) represent a single disease process that is modified by host factors (including host immunoregulation) to cause the range of clinical phenotypes seen. The impact of PIC on the patient is highly variable, with outcome ranging from complete spontaneous recovery to bilateral severe sight-loss. Detection and monitoring has been greatly facilitated by modern scanning techniques, especially OCT and autofluorescence imaging, and may be enhanced by co-registration of sequential images to detect change over time. Depending on the course of disease and nature of complications, appropriate treatment may range from observation to systemic immunosuppression and anti-angiogenic therapies. PIC is a challenging condition where treatment has to be tailored to the patient's individual circumstances, the extent of disease, and the risk of progression.

Type: Article
Title: Punctate Inner Choroidopathy: A Review
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.survophthal.2016.10.003
Publisher version: http://dx.doi.org/10.1016/j.survophthal.2016.10.00...
Language: English
Additional information: Copyright © 2016 Elsevier Inc. All rights reserved.
Keywords: Punctate inner choroidopathy, choroidal neovascularization, posterior uveitis, white dot syndromes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1524795
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