Chitnis, D;
Cooper, RJ;
Dempsey, L;
Powell, S;
Quaggia, S;
Highton, D;
Elwell, C;
... Everdell, NL; + view all
(2016)
Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system.
Biomedical Optics Express
, 7
(10)
pp. 4275-4288.
10.1364/BOE.7.004275.
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Abstract
We present the first three-dimensional, functional images of the human brain to be obtained using a fibre-less, high-density diffuse optical tomography system. Our technology consists of independent, miniaturized, silicone-encapsulated DOT modules that can be placed directly on the scalp. Four of these modules were arranged to provide up to 128, dual-wavelength measurement channels over a scalp area of approximately 60 × 65 mm2. Using a series of motor-cortex stimulation experiments, we demonstrate that this system can obtain high-quality, continuous-wave measurements at source-detector separations ranging from 14 to 55 mm in adults, in the presence of hair. We identify robust haemodynamic response functions in 5 out of 5 subjects, and present diffuse optical tomography images that depict functional haemodynamic responses that are well-localized in all three dimensions at both the individual and group levels. This prototype modular system paves the way for a new generation of wearable, wireless, high-density optical neuroimaging technologies.
| Type: | Article |
|---|---|
| Title: | Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/BOE.7.004275 |
| Publisher version: | https://doi.org/10.1364/BOE.7.004275 |
| Language: | English |
| Additional information: | Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. This is the peer reviewed version of the following article: Danial Chitnis, Robert J. Cooper, Laura Dempsey, Samuel Powell, Simone Quaggia, David Highton, Clare Elwell, Jeremy C. Hebden, and Nicholas L. Everdell, "Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system," Biomed. Opt. Express 7, 4275-4288 (2016), which has been published in final form at https://doi.org/10.1364/BOE.7.004275. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1522441 |
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