Gatta, AT;
Levine, TP;
(2017)
Piecing Together the Patchwork of Contact Sites.
Trends in Cell Biology
, 27
(3)
pp. 214-229.
10.1016/j.tcb.2016.08.010.
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Abstract
Contact sites are places where two organelles join together to carry out a shared activity requiring nonvesicular communication. A large number of contact sites have been discovered, and almost any two organelles can contact each other. General rules about contacts include constraints on bridging proteins, with only a minority of bridges physically creating contacts by acting as 'tethers'. The downstream effects of contacts include changing the physical behaviour of organelles, and also forming biochemically heterogeneous subdomains. However, some functions typically localized to contact sites, such as lipid transfer, have no absolute requirement to be situated there. Therefore, the key aspect of contacts is the directness of communication, which allows metabolic channelling and collective regulation.
| Type: | Article |
|---|---|
| Title: | Piecing Together the Patchwork of Contact Sites |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tcb.2016.08.010 |
| Publisher version: | http://dx.doi.org/10.1016/j.tcb.2016.08.010 |
| Language: | English |
| Additional information: | Copyright © 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | biological transport, intracellular membranes/metabolism, membrane lipids/metabolism, nonvesicular traffic, vesicular transport |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1522333 |
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