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A linear model for event-related respiration responses

Bach, DR; Gerster, S; Tzovara, A; Castegnetti, G; (2016) A linear model for event-related respiration responses. Journal of Neuroscience Methods , 270 pp. 147-155. 10.1016/j.jneumeth.2016.06.001. Green open access

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Abstract

Background Cognitive processes influence respiratory physiology. This may allow inferring cognitive states from measured respiration. Here, we take a first step towards this goal and investigate whether event-related respiratory responses can be identified, and whether they are accessible to a model-based approach. New method We regard respiratory responses as the output of a linear time invariant system that receives brief inputs after psychological events. We derive average responses to visual targets, aversive stimulation, and viewing of arousing pictures, in interpolated respiration period (RP), respiration amplitude (RA), and respiratory flow rate (RFR). We then base a Psychophysiological Model (PsPM) on these averaged event-related responses. The PsPM is inverted to yield estimates of cognitive input into the respiratory system. This method is validated in an independent data set. Results All three measures show event-related responses, which are captured as non-zero response amplitudes in the PsPM. Amplitude estimates for RA and RFR distinguish between picture viewing and the other tasks. This pattern is replicated in the validation experiment. Comparison with existing methods Existing respiratory measures are based on relatively short time-intervals after an event while the new method is based on the entire duration of respiratory responses. Conclusion Our findings suggest that interpolated respiratory measures show replicable event-related response patterns. PsPM inversion is a suitable approach to analysing these patterns, with a potential to infer cognitive processes from respiration.

Type: Article
Title: A linear model for event-related respiration responses
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jneumeth.2016.06.001
Publisher version: http://dx.doi.org/10.1016/j.jneumeth.2016.06.001
Language: English
Additional information: © 2016 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemical Research Methods, Neurosciences, Biochemistry & Molecular Biology, Neurosciences & Neurology, Respiration, Gas exchange, Respiration rate, Tidal volume, Minute volume, Evoked responses, Psychophysiology, Psychophysiological Model, SKIN-CONDUCTANCE RESPONSES, ORIENTING RESPONSE, PSYCHOPHYSIOLOGY, STIMULI, ASTHMA, FMRI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1522233
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