Diemoz, PC; Bravin, A; Sztrókay-Gaul, A; Ruat, M; Grandl, S; Mayr, D; Auweter, S; ... Olivo, A; + view all Diemoz, PC; Bravin, A; Sztrókay-Gaul, A; Ruat, M; Grandl, S; Mayr, D; Auweter, S; Mittone, A; Brun, E; Ponchut, C; Reiser, MF; Coan, P; Olivo, A; - view fewer (2016) A method for high-energy, low-dose mammography using edge illumination x-ray phase-contrast imaging. Physics in Medicine and Biology , 61 , Article 8750. 10.1088/1361-6560/61/24/8750.

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Abstract

Since the breast is one of the most radiosensitive organs, mammography is arguably the area where lowering radiation dose is of the uttermost importance. Phase-based x-ray imaging methods can provide opportunities in this sense, since they do not require x-rays to be stopped in tissue for image contrast to be generated. Therefore, x-ray energy can be considerably increased compared to those usually exploited by conventional mammography. In this article we show how a novel, optimized approach can lead to considerable dose reductions. This was achieved by matching the edge-illumination phase method, which reaches very high angular sensitivity also at high x-ray energies, to an appropriate image processing algorithm and to a virtually noise-free detection technology capable of reaching almost 100% efficiency at the same energies. Importantly, while proof-of-concept was obtained at a synchrotron, the method has potential for a translation to conventional sources.

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