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Cardiac computed tomography for the detection of cardiac amyloidosis

Rosmini, S; Treibel, TA; Bandula, S; Stroud, T; Fontana, M; Hawkins, PN; Moon, JC; (2016) Cardiac computed tomography for the detection of cardiac amyloidosis. Journal of Cardiovascular Computed Tomography , 11 (2) pp. 155-156. 10.1016/j.jcct.2016.09.001. Green open access

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Abstract

A 67-year-old Caucasian man presented with atrial flutter on routine 12-lead electrocardiography (ECG). Following appropriate anticoagulation, he successfully underwent atrial flutter ablation. Echocardiography during the admission showed concentric left ventricular (LV) hypertrophy with severely impaired LV systolic function, particularly longitudinal (Figure 1A, video 1), and biatrial dilatation. Due to episodes of non-sustained ventricular tachycardia, he was fitted with an implantable cardioverter-defibrillator (ICD). The ECG QRS complexes on peripheral leads were small compared to the structural wall thickening on echocardiography (Figure 1B) raising the suspicion of cardiac amyloidosis. Preliminary evaluation excluded a plasma cell dyscrasia (negative serum free light chains changes and urinary Bence-Jones protein). Serum amyloid P component (SAP) scintigraphy was negative for visceral organ uptake and bone tracer scintigraphy (Technetium-DPD) was positive with Perugini Grade 2-3 uptake (Figure 1C), consistent with a diagnosis of cardiac transthyretin amyloidosis (ATTR). Cardiac magnetic resonance (CMR) was contra-indicated due to the non-conditional ICD (Figure 1D). After giving fully informed written consent, cardiac computed tomography (CCT) was performed as part of a research study, using a three step protocol (Figure 1E) as previously described1, allowing calculation of the extracellular volume fraction (ECV) from pre- and 5-minutes post-contrast images. The septal ECV, calculated from a co-registered, segmented myocardial mask displaying pixel-by-pixel ECV values, was in the amyloid spectrum elevated at 63% (Figure 1F), Gene sequencing revealed a heterozygous V122I mutation, confirming the diagnosis of familial amyloid cardiomyopathy (ATTR).

Type: Article
Title: Cardiac computed tomography for the detection of cardiac amyloidosis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jcct.2016.09.001
Publisher version: http://doi.org/10.1016/j.jcct.2016.09.001
Language: English
Additional information: Copyright © 2016. Published by Elsevier Inc. on behalf of Society of Cardiovascular Computed Tomography. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Cardiac amyloid, Computed tomography
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/1521708
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