Zomer, E;
Leach, R;
Trimmer, C;
Lobstein, T;
Morris, S;
James, WP;
Finer, N;
(2017)
Effectiveness and cost-effectiveness of interventions that cause weight loss and reduce the risk of cardiovascular disease.
Diabetes, Obesity and Metabolism
, 19
(1)
pp. 118-124.
10.1111/dom.12792.
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Abstract
BACKGROUND: Overweight/obesity is associated with significant morbidity, mortality and costs. Weight loss has been shown to reverse some of these effects, reducing the risk of chronic diseases such as cardiovascular disease (CVD). We aimed to determine potential monies available, from an English National Health Service perspective, for weight loss interventions to be cost-effective in the prevention of CVD. METHODS: A Markov model was developed, populated with overweight/obese individuals from the Health Survey for England aged 30-74 years, free of pre-existing CVD, and with available risk factor information to calculate CVD risk. All individuals were free of CVD at baseline and with each annual cycle, could transition to other health states of primary CVD, secondary CVD or death according to transition probabilities for a maximum period of ten years, or until death. Utilities, costs and the effects of weight loss on CVD risk factors were applied. The potential monies available for CVD prevention strategies provided the incremental cost-effectiveness ratio met UK arbitrary limits of between £20 000 and £30 000 was determined. RESULTS: Applying the effects of weight loss on CVD risk factors prevented 12 CVD events and saved 12 quality-adjusted life years over 10 years per 1 000 individuals. £27-£39 was available per person per year for up to 10 years when meeting the UK arbitrary limits. CONCLUSIONS: Individual annual financial allowances for weight loss interventions to be considered cost-effective is relatively low; however, as a large proportion of the population is affected, wide cheap societal interventions are important.
| Type: | Article |
|---|---|
| Title: | Effectiveness and cost-effectiveness of interventions that cause weight loss and reduce the risk of cardiovascular disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/dom.12792 |
| Publisher version: | http://dx.doi.org/10.1111/dom.12792 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Zomer E , Leach R , Trimmer C , Lobstein T , Morris S , James WP and Finer N . Effectiveness and cost-effectiveness of interventions that cause weight loss and reduce the risk of cardiovascular disease, Diabetes Obes Metab, 2016, which has been published in final form at http://dx.doi.org/10.1111/dom.12792. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1521700 |
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