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Studies of G-quadruplexes formed within self-assembled DNA mini-circles

Klejevskaja, B; Pyne, ALB; Reynolds, M; Shivalingam, A; Thorogate, R; Hoogenboom, BW; Ying, L; (2016) Studies of G-quadruplexes formed within self-assembled DNA mini-circles. Chemical Communications , 52 (84) pp. 12454-12457. 10.1039/c6cc07110d. Green open access

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Abstract

We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.

Type: Article
Title: Studies of G-quadruplexes formed within self-assembled DNA mini-circles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c6cc07110d
Publisher version: http://dx.doi.org/10.1039/c6cc07110d
Language: English
Additional information: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Keywords: Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, TELOMERIC G-QUADRUPLEX, SMALL-MOLECULE, FUNCTIONALIZATION, TRANSCRIPTION, MINICIRCLES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1521444
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