Fernandez Garcia, C;
Powner, MW;
(2017)
Selective Acylation of Nucleosides, Nucleotides, and Glycerol-3- phosphocholine in Water.
Synlett
, 28
(1)
pp. 78-83.
10.1055/s-0036-1588626.
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Abstract
A convenient selective synthesis of 2′,3′-di-O-acetyl-nucleo- tide-5′-phosphates, 2′,3′-di-O-acetyl-nucleotide-5′-triphosphates and 2′,3′,5′-tri-O-acetyl-nucleosides in water has been developed. Further- more, a long-chain selective glycerol-3-phosphocholine diacylation is elucidated. These reactions are environmentally benign, rapid, high yielding, and the products are readily purified. Importantly, this reac- tion may indicate a prebiotically plausible reaction pathway for the se- lective acylation of key metabolites to facilitate their incorporation into protometabolism.
| Type: | Article |
|---|---|
| Title: | Selective Acylation of Nucleosides, Nucleotides, and Glycerol-3- phosphocholine in Water |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1055/s-0036-1588626 |
| Publisher version: | http://dx.doi.org/10.1055/s-0036-1588626 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | prebiotic chemistry, nucleotides, lipids, water, acylation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1520910 |
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