Powner, MW;
Coggins, AJ;
(2017)
Prebiotic synthesis of phosphoenol pyruvate by α-phosphorylation-controlled triose glycolysis.
Nature Chemistry
, 9
(4)
pp. 310-317.
10.1038/nchem.2624.
Preview |
Text
FINAL_ACCEPTED_PEP_NAT_CHEM_MANUSCRIPT.pdf - Accepted Version Download (775kB) | Preview |
Abstract
Phosphoenol pyruvate is the highest-energy phosphate found in living organisms and is one of the most versatile molecules in metabolism. Consequently, it is an essential intermediate in a wide variety of biochemical pathways, including carbon fixation, the shikimate pathway, substrate-level phosphorylation, gluconeogenesis and glycolysis. Triose glycolysis (generation of ATP from glyceraldehyde 3-phosphate via phosphoenol pyruvate) is among the most central and highly conserved pathways in metabolism. Here, we demonstrate the efficient and robust synthesis of phosphoenol pyruvate from prebiotic nucleotide precursors, glycolaldehyde and glyceraldehyde. Furthermore, phosphoenol pyruvate is derived within an α-phosphorylation controlled reaction network that gives access to glyceric acid 2-phosphate, glyceric acid 3-phosphate, phosphoserine and pyruvate. Our results demonstrate that the key components of a core metabolic pathway central to energy transduction and amino acid, sugar, nucleotide and lipid biosyntheses can be reconstituted in high yield under mild, prebiotically plausible conditions.
| Type: | Article |
|---|---|
| Title: | Prebiotic synthesis of phosphoenol pyruvate by α-phosphorylation-controlled triose glycolysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nchem.2624 |
| Publisher version: | http://doi.org/10.1038/nchem.2624 |
| Language: | English |
| Additional information: | Copyright © 2016© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. All rights reserved. The final publication is available at Nature Chemistry (2016) via http://dx.doi.org/10.1038/nchem.2624 |
| Keywords: | Organic chemistry, Chemical origin of life |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1520873 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
