Yeung, RS; Albani, S; Feldman, BM; Mellins, E; Prakken, B; Wedderburn, LR; (2016) Enhancing translational research in paediatric rheumatology through standardization. Nature Reviews Rheumatology , 12 (11) pp. 684-690. 10.1038/nrrheum.2016.156.

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Abstract

The past decade has seen many successes in translational rheumatology, from dramatic improvements in outcomes brought about by novel biologic therapies, to the discovery of new monogenic inflammatory disorders. Advances in molecular medicine, combined with progress towards precision care, provide an excellent opportunity to accelerate the translation of biological understanding to the bedside. However, although the field of rheumatology is a leader in the standardization of data collection and measures of disease activity, it lags behind in standardization of biological sample collection and assay performance. Uniform approaches are necessary for robust collaborative research, particularly in rare diseases. Standardization is also critical to increase reproducibility between centres, a prerequisite for clinical implementation of translational research. This Perspectives article emphasizes the need for standardization and implementation of best practices, presented in the context of lessons learned from international biorepository networks.

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