UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Breast cancer in systemic lupus

Bernatsky, S; Ramsey-Goldman, R; Petri, M; Urowitz, MB; Gladman, DD; Fortin, PF; Ginzler, E; ... Clarke, AE; + view all (2016) Breast cancer in systemic lupus. Lupus , 26 (3) pp. 311-315. 10.1177/0961203316664595. Green open access

[thumbnail of Rahman_Breast Cancer in SLE.pdf]
Preview
Text
Rahman_Breast Cancer in SLE.pdf

Download (210kB) | Preview

Abstract

OBJECTIVE: There is a decreased breast cancer risk in systemic lupus erythematosus (SLE) versus the general population. We assessed a large sample of SLE patients, evaluating demographic and clinical characteristics and breast cancer risk. METHODS: We performed case-cohort analyses within a multi-center international SLE sample. We calculated the breast cancer hazard ratio (HR) in female SLE patients, relative to demographics, reproductive history, family history of breast cancer, and time-dependent measures of anti-dsDNA positivity, cumulative disease activity, and drugs, adjusted for SLE duration. RESULTS: There were 86 SLE breast cancers and 4498 female SLE cancer-free controls. Patients were followed on average for 7.6 years. Versus controls, SLE breast cancer cases tended to be white and older. Breast cancer cases were similar to controls regarding anti-dsDNA positivity, disease activity, and most drug exposures over time. In univariate and multivariate models, the principal factor associated with breast cancers was older age at cohort entry. CONCLUSIONS: There was little evidence that breast cancer risk in this SLE sample was strongly driven by any of the clinical factors that we studied. Further search for factors that determine the lower risk of breast cancer in SLE may be warranted.

Type: Article
Title: Breast cancer in systemic lupus
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0961203316664595
Publisher version: http://doi.org/10.1177/0961203316664595
Language: English
Additional information: © The Author(s), 2016.
Keywords: Breast cancer, systemic lupus erythematosus
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1519947
Downloads since deposit
100Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item