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Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering.

Bagdadi, AV; Safari, M; Dubey, P; Basnett, P; Sofokleous, P; Humphrey, E; Locke, I; ... Roy, I; + view all (2016) Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering. J Tissue Eng Regen Med 10.1002/term.2318. (In press). Green open access

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Abstract

Cardiac tissue engineering (CTE) is currently a prime focus of research due to an enormous clinical need. In this work, a novel functional material, Poly(3-hydroxyoctanoate), P(3HO), a medium chain length polyhydroxyalkanoate (PHA), produced using bacterial fermentation, was studied as a new potential material for CTE. Engineered constructs with improved mechanical properties, crucial for supporting the organ during new tissue regeneration, and enhanced surface topography, to allow efficient cell adhesion and proliferation, were fabricated. Our results showed that the mechanical properties of the final patches were close to that of cardiac muscle. Biocompatibility of the P(3HO) neat patches, assessed using Neonatal ventricular rat myocytes (NVRM), showed that the polymer was as good as collagen in terms of cell viability, proliferation and adhesion. Enhanced cell adhesion and proliferation properties were observed when porous and fibrous structures were incorporated to the patches. Also, no deleterious effect was observed on the adults cardiomyocytes' contraction when cardiomyocytes were seeded on the P(3HO) patches. Hence, P(3HO) based multifunctional cardiac patches are promising constructs for efficient CTE. This work will provide a positive impact on the development of P(3HO) and other PHAs as a novel new family of biodegradable functional materials with huge potential in a range of different biomedical applications, particularly CTE, leading to further interest and exploitation of these materials.

Type: Article
Title: Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/term.2318
Additional information: This is the peer reviewed version of the following article: Bagdadi, A. V., Safari, M., Dubey, P., Basnett, P., Sofokleous, P., Humphrey, E., Locke, I., Edirisinghe, M., Terracciano, C., Boccaccini, A. R., Knowles, J. C., Harding, S. E., and Roy, I. (2016) Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering. J Tissue Eng Regen Med, which has been published in final form at doi: 10.1002/term.2318. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Cardiac Tissue Engineering, Poly(3-hydroxyoctanoate), Polyhydroxyalkanoates, cardiac patches
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1519646
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