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Time course and frequency specificity of sub-cortical plasticity in adults following acute unilateral deprivation

Brotherton, H; Plack, CJ; Schaette, R; Munro, KJ; (2016) Time course and frequency specificity of sub-cortical plasticity in adults following acute unilateral deprivation. Hearing Research , 341 pp. 210-219. 10.1016/j.heares.2016.09.003. Green open access

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Abstract

Auditory deprivation and stimulation can change the threshold of the acoustic reflex, but the mechanisms underlying these changes remain largely unknown. In order to elucidate the mechanism, we sought to characterize the time-course as well as the frequency specificity of changes in acoustic reflex thresholds (ARTs). In addition, we compared ipsilateral and contralateral measurements because the pattern of findings may shed light on the anatomical location of the change in neural gain. Twenty-four normal-hearing adults wore an earplug continuously in one ear for six days. We measured ipsilateral and contralateral ARTs in both ears on six occasions (baseline, after 2, 4 and 6 days of earplug use, and 4 and 24 h after earplug removal), using pure tones at 0.5, 1, 2 and 4 kHz and a broadband noise stimulus, and an experimenter-blinded design. We found that ipsi- as well as contralateral ARTs were obtained at a lower sound pressure level after earplug use, but only when the reflex was elicited by stimulating the treatment ear. Changes in contralateral ARTs were not the same as changes in ipsilateral ARTs when the stimulus was presented to the control ear. Changes in ARTs were present after 2 days of earplug use, and reached statistical significance after 4 days, when the ipsilateral and contralateral ARTs were measured in the treatment ear. The greatest changes in ARTs occurred at 2 and 4 kHz, the frequencies most attenuated by the earplug. After removal of the earplug, ARTs started to return to baseline relatively quickly, and were not significantly different from baseline by 4–24 h. There was a trend for the recovery to occur quicker than the onset. The changes in ARTs are consistent with a frequency-specific gain control mechanism operating around the level of the ventral cochlear nucleus in the treatment ear, on a time scale of hours to days. These findings, specifically the time course of change, could be applicable to other sensory systems, which have also shown evidence of a neural gain control mechanism.

Type: Article
Title: Time course and frequency specificity of sub-cortical plasticity in adults following acute unilateral deprivation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.heares.2016.09.003
Publisher version: http://doi.org/10.1016/j.heares.2016.09.003
Language: English
Additional information: Crown Copyright © 2016 Published by Elsevier B.V. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Audiology & Speech-Language Pathology, Neurosciences, Otorhinolaryngology, Neurosciences & Neurology, Unilateral deprivation, Neural gain, Subcortical plasticity, VENTRAL COCHLEAR NUCLEUS, SPONTANEOUS NEURAL ACTIVITY, CENTRAL AUDITORY PATHWAYS, HEARING-LOSS, COMPUTATIONAL MODEL, BRAIN-STEM, NEURONAL HYPERACTIVITY, HOMEOSTATIC PLASTICITY, ADAPTIVE PLASTICITY, ACOUSTIC TRAUMA
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1518548
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