Feasey, NA;
Hadfield, J;
Keddy, KH;
Dallman, TJ;
Jacobs, J;
Deng, X;
Wigley, P;
... Thomson, NR; + view all
(2016)
Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.
Nature Genetics
, 48
(10)
pp. 1211-1217.
10.1038/ng.3644.
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Abstract
An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
| Type: | Article |
|---|---|
| Title: | Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ng.3644 |
| Publisher version: | http://dx.doi.org/10.1038/ng.3644 |
| Language: | English |
| Additional information: | Copyright © 2016 Nature America, Inc. All rights reserved |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, Enterica Serovar Enteritidis, Nontyphoidal Salmonella, Serotype Enteritidis, Typhimurium St313, Host Adaptation, United-kingdom, Evolution, Epidemic, Africa, Surveillance |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1517901 |
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