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Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing

Oberhuber, M; Hope, TMH; Seghier, ML; Jones, OP; Prejawa, S; Green, DW; Price, CJ; (2016) Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing. Cerebral Cortex , 26 (11) pp. 4212-4226. 10.1093/cercor/bhw251. Green open access

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Abstract

We used fMRI in 85 healthy participants to investigate whether different parts of the left supramarginal gyrus (SMG) are involved in processing phonological inputs and outputs. The experiment involved 2 tasks (speech production (SP) and one-back (OB) matching) on 8 different types of stimuli that systematically varied the demands on sensory processing (visual vs. auditory), sublexical phonological input (words and pseudowords vs. nonverbal stimuli), and semantic content (words and objects vs. pseudowords and meaningless baseline stimuli). In ventral SMG, we found an anterior subregion associated with articulatory sequencing (for SP > OB matching) and a posterior subregion associated with auditory short-term memory (for all auditory > visual stimuli and written words and pseudowords > objects). In dorsal SMG, a posterior subregion was most highly activated by words, indicating a role in the integration of sublexical and lexical cues. In anterior dorsal SMG, activation was higher for both pseudoword reading and object naming compared with word reading, which is more consistent with executive demands than phonological processing. The dissociation of these four “functionally-distinct” regions, all within left SMG, has implications for differentiating between different types of phonological processing, understanding the functional anatomy of language and predicting the effect of brain damage.

Type: Article
Title: Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhw251
Publisher version: http://doi.org/10.1093/cercor/bhw251
Language: English
Additional information: © The Author 2016. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, functional MRI, language, parietal lobe, phonological processing, speech production, TRANSCRANIAL MAGNETIC STIMULATION, INFERIOR PARIETAL CORTEX, SEMANTIC SYSTEM, WORKING-MEMORY, BRAIN, FMRI, RECOGNITION, NETWORK, TASK, PARCELLATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1517632
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