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Double oscillating diffusion encoding and sensitivity to microscopic anisotropy

Ianuş, A; Shemesh, N; Alexander, DC; Drobnjak, I; (2017) Double oscillating diffusion encoding and sensitivity to microscopic anisotropy. Magnetic Resonance in Medicine , 78 (2) pp. 550-564. 10.1002/mrm.26393. Green open access

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Abstract

PURPOSE: To introduce a novel diffusion pulse sequence, namely double oscillating diffusion encoding (DODE), and to investigate whether it adds sensitivity to microscopic diffusion anisotropy (µA) compared to the well-established double diffusion encoding (DDE) methodology. METHODS: We simulate measurements from DODE and DDE sequences for different types of microstructures exhibiting restricted diffusion. First, we compare the effect of varying pulse sequence parameters on the DODE and DDE signal. Then, we analyse the sensitivity of the two sequences to the microstructural parameters (pore diameter and length) which determine µA. Finally, we investigate specificity of measurements to particular substrate configurations. RESULTS: Simulations show that DODE sequences exhibit similar signal dependence on the relative angle between the two gradients as DDE sequences, however, the effect of varying the mixing time is less pronounced. The sensitivity analysis shows that in substrates with elongated pores and various orientations, DODE sequences increase the sensitivity to pore diameter, while DDE sequences are more sensitive to pore length. Moreover, DDE and DODE sequence parameters can be tailored to enhance/suppress the signal from a particular range of substrates. CONCLUSIONS: A combination of DODE and DDE sequences maximize sensitivity to µA, compared to using just the DDE method. Magn Reson Med, 2016. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

Type: Article
Title: Double oscillating diffusion encoding and sensitivity to microscopic anisotropy
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mrm.26393
Publisher version: http://dx.doi.org/10.1002/mrm.26393
Language: English
Additional information: © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: MRI, OGSE, double diffusion encoding, double-PFG, microscopic anisotropy, microstructure, multiple diffusion encoding, oscillating gradient spin echo
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1516997
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