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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Mallick, S; Li, H; Lipson, M; Mathieson, I; Gymrek, M; Racimo, F; Zhao, M; ... Reich, D; + view all (2016) The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature , 538 (7624) pp. 201-206. 10.1038/nature18964. Green open access

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Abstract

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.

Type: Article
Title: The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nature18964
Publisher version: http://dx.doi.org/10.1038/nature18964
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Keywords: Genetics, Genetic variation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1516771
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