te Molder, M;
de Hoog, MLA;
Uiterwaal, CSPM;
van der Ent, CK;
Smit, HA;
Schilder, AGM;
Damoiseaux, RAMJ;
(2016)
Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences.
PLoS ONE
, 11
(9)
10.1371/journal.pone.0160560.
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Abstract
OBJECTIVES: Antibiotic treatment of acute otitis media (AOM) has been suggested to increase the risk of future AOM episodes by causing unfavorable shifts in microbial flora. Because current evidence on this topic is inconclusive and long-term follow-up data are scarce, we wanted to estimate the effect of antibiotic treatment for a first AOM episode occurring during infancy on AOM recurrences and AOM-related health care utilization later in life. METHODS: We obtained demographic information and risk factors from data of the Wheezing Illnesses Study Leidsche Rijn, a prospective birth cohort study in which all healthy newborns born in Leidsche Rijn (between 2001 and 2012), The Netherlands, were enrolled. These data were linked to children’s primary care electronic health records up to the age of four. Children with at least one family physician-diagnosed AOM episode before the age of two were included in analyses. The exposure of interest was the prescription of oral antibiotics (yes vs no) for a child’s first AOM episode before the age of two years. RESULTS: 848 children were included in analyses and 512 (60%) children were prescribed antibiotics for their first AOM episode. Antibiotic treatment was not associated with an increased risk of total AOM recurrences (adjusted rate ratio: 0.94, 95% CI: 0.78–1.13), recurrent AOM (≥3 episodes in 6 months or ≥4 in one year; adjusted risk ratio: 0.79, 95% CI: 0.57–1.11), or with increased AOM-related health care utilization during children’s first four years of life. CONCLUSIONS: Oral antibiotic treatment of a first AOM episode occurring during infancy does not affect the number of AOM recurrences and AOM-related health care utilization later in life. This information can be used when weighing the pros and cons of various AOM treatment options.
| Type: | Article |
|---|---|
| Title: | Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0160560 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0160560 |
| Language: | English |
| Additional information: | © 2016 te Molder et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, RESPIRATORY-TRACT INFECTIONS, STREPTOCOCCUS-PNEUMONIAE, NASOPHARYNGEAL CARRIAGE, CONTROLLED-TRIAL, PRIMARY-CARE, CHILDREN, COHORT, THERAPY, CONSULTATIONS, MASTOIDITIS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1516732 |
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