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AplusB: A Web Application for Investigating A plus B Designs for Phase I Cancer Clinical Trials

Wheeler, GM; Sweeting, MJ; Mander, AP; (2016) AplusB: A Web Application for Investigating A plus B Designs for Phase I Cancer Clinical Trials. PLOS ONE , 11 (7) , Article e0159026. 10.1371/journal.pone.0159026. Green open access

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Abstract

In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.

Type: Article
Title: AplusB: A Web Application for Investigating A plus B Designs for Phase I Cancer Clinical Trials
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0159026
Publisher version: http://dx.doi.org/10.1371/journal.pone.0159026
Language: English
Additional information: Copyright: © 2016 Wheeler et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CONTINUAL REASSESSMENT METHOD, ONCOLOGY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre
URI: https://discovery.ucl.ac.uk/id/eprint/1516211
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