Roughead, EE;
Chan, EW;
Choi, NK;
Griffiths, J;
Jin, XM;
Lee, J;
Kimura, M;
... Pratt, NL; + view all
(2016)
Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis.
Expert Opinion on Drug Safety
, 15
(12)
pp. 1589-1595.
10.1080/14740338.2016.1238071.
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Expert Opinion on Drug Safety Accepted Manuscript 2016 Proton pump inhibitors and risk of Clostridium difficile infection a multi country study using sequence symmetry analysis.pdf - Accepted Version Download (706kB) | Preview |
Abstract
OBJECTIVE: To determine the association between incident proton pump inhibitor (PPI) use and Clostridium difficile infections across multiple countries Method: National data covering the total population in Australia and Korea, the Canadian population over 65 years and a 3 million person random sample data set from Taiwan were assessed, as were data from a worker insurance population and a hospital inpatient/outpatient population in Japan. Sequence symmetry analysis was used to assess the association with oral vancomycin dispensing as the outcome of interest. RESULTS: 54,957 patients were included. Positive associations were observed in Australia; adjusted sequence ratio (ASR) 2.48 (95% CI 1.90, 3.12), Korea ASR 2.15 (95%CI 2.11, 2.19), Canada ASR 1.45 (95% CI 1.16, 1.79), Japan hospital dataset ASR 3.21 (95%CI 2.12, 4.55) and Japan worker insurance dataset ASR 5.40 (95% CI 2.73, 8.75). The pooled result was ASR 2.40 (95%CI 1.88, 3.05) and 3.16 (95%CI 1.95, 5.10) when limited to Japan, Korean and Taiwan. Results did not vary by individual PPI. The temporal analysis showed effects within the first two weeks of PPI initiation. CONCLUSION: Our study confirms the association between PPI initiation and C. difficile infections across countries in the Asia-Pacific region.
| Type: | Article |
|---|---|
| Title: | Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/14740338.2016.1238071 |
| Publisher version: | http://dx.doi.org/10.1080/14740338.2016.1238071 |
| Language: | English |
| Additional information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Drug Safety on 27 September 2016, available online: http://www.tandfonline.com/10.1080/14740338.2016.1238071. |
| Keywords: | Asia, Clostridium difficile, Proton pump inhibitors, adverse event, sequence symmetry analysis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1516145 |
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