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Noncoding RNAs and Duchenne muscular dystrophy

Perry, MM; Muntoni, F; (2016) Noncoding RNAs and Duchenne muscular dystrophy. Epigenomics , 8 (11) pp. 1527-1537. 10.2217/epi-2016-0088. Green open access

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Abstract

Noncoding RNAs (ncRNAs) such as miRNAs and long noncoding RNAs modulate gene transcription in response to environmental stressors and other stimuli. A role for ncRNAs in muscle pathologies has been demonstrated and further evidence suggests that ncRNAs also play a role in Duchenne muscular dystrophy (DMD). Studies investigating the differential expression of miRNAs in biological fluids between DMD patients and models of dystrophin deficiency (the MDX mouse model, canine models of DMD) and controls have been published, as these have a role in fibrosis. Long noncoding RNAs are differentially expressed in DMD patients and may, in part, have a mechanism of action via targeting of miRNAs. Although many of these recent findings need to be confirmed, ncRNAs may prove to be useful as potential biomarkers of disease. However, their use as therapeutic targets in DMD remains unclear.

Type: Article
Title: Noncoding RNAs and Duchenne muscular dystrophy
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/epi-2016-0088
Publisher version: http://doi.org/10.2217/epi-2016-0088
Language: English
Keywords: Duchenne muscular dystrophy, GRMD dog, MDX mice, lncRNA, miRNA
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1514884
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