UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Challenges in the management of pediatric blepharokeratoconjunctivis / ocular rosacea

Daniel, MC; O’Gallagher, M; Hingorani, M; Dahlmann-Noor, A; Tuft, S; (2016) Challenges in the management of pediatric blepharokeratoconjunctivis / ocular rosacea. Expert Review of Ophthalmology , 11 (4) pp. 299-309. 10.1080/17469899.2016.1209408. Green open access

[thumbnail of Tuft_Challenges in the management of pediatric blepharokeratoconjunctivis ocular rosacea.pdf]
Preview
Text
Tuft_Challenges in the management of pediatric blepharokeratoconjunctivis ocular rosacea.pdf - Published Version

Download (1MB) | Preview

Abstract

Introduction: Childhood blepharokeratoconjunctivitis is a common lid margin inflammation with secondary ocular surface disease. Its etiology is unclear and there are no randomized controlled trials to support the superiority of any treatment option. / Areas covered: We searched the following databases; Cochrane Central Register of Controlled Trials, Ovid MEDLINE and affiliated Ovid databases, EMBASE, the ISRCTN registry, Clinical- Trials.gov and the World Health Organization International Clinical Trials Registry Platform. Due to the paucity of pediatric data we also considered information from articles focused on adults. / Expert commentary: Treatment is based on the assumption that the mechanisms of BKC and rosacea keratitis are the same: meibomian gland dysfunction, bacterial colonisation of the lid margin, delayed type hypersensitivity, Demodex folliculorum, genetic predisposition and Toll-like receptors inducing release of pro-inflammatory cytokines. Generally accepted grading scales are needed. Randomized clinical trials are needed to evaluate treatment options. The effects of antibiotics, immunomodulators, osmoprotectants and essential fatty acids need further investigation.

Type: Article
Title: Challenges in the management of pediatric blepharokeratoconjunctivis / ocular rosacea
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/17469899.2016.1209408
Publisher version: http://dx.doi.org/10.1080/17469899.2016.1209408
Language: English
Additional information: Copyright © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
Keywords: Blepharokeratoconjunctivitis, blepharoconjunctivitis, blepharitis, dry eye disease, meibomian gland disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1514588
Downloads since deposit
314Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item