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Does true Gleason pattern 3 merit its cancer descriptor?

Miah, S; Ahmed, HU; Freeman, A; Emberton, M; (2016) Does true Gleason pattern 3 merit its cancer descriptor? Nature Reviews Urology , 13 (9) pp. 541-548. 10.1038/nrurol.2016.141. Green open access

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Abstract

Nearly five decades following its conception, the Gleason grading system remains a cornerstone in the prognostication and management of patients with prostate cancer. In the past few years, a debate has been growing whether Gleason score 3 + 3 = 6 prostate cancer is a clinically significant disease. Clinical, molecular and genetic research is addressing the question whether well characterized Gleason score 3 + 3 = 6 disease has the ability to affect the morbidity and quality of life of an individual in whom it is diagnosed. The consequences of treatment of Gleason score 3 + 3 = 6 disease are considerable; few men get through their treatments without sustaining some harm. Further modification of the classification of prostate cancer and dropping the label cancer for Gleason score 3 + 3 = 6 disease might be warranted.

Type: Article
Title: Does true Gleason pattern 3 merit its cancer descriptor?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrurol.2016.141
Publisher version: http://doi.org/10.1038/nrurol.2016.141
Language: English
Additional information: © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Keywords: Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, LOCALIZED PROSTATE-CANCER, PAPILLARY UROTHELIAL NEOPLASMS, 2005 INTERNATIONAL-SOCIETY, POPULATION-BASED COHORT, RADICAL PROSTATECTOMY, NEEDLE-BIOPSY, ACTIVE SURVEILLANCE, INTEROBSERVER REPRODUCIBILITY, GRADING SYSTEM, CLONAL ORIGIN, Diagnosis, Diagnostic markers, Prognosis, Prostate cancer
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1513331
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