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Event-related potentials and cognition in Parkinson's disease: An integrative review

Seer, C; Lange, F; Georgiev, D; Jahanshahi, M; Kopp, B; (2016) Event-related potentials and cognition in Parkinson's disease: An integrative review. Neuroscience & Biobehavioral Reviews , 71 pp. 691-714. 10.1016/j.neubiorev.2016.08.003. Green open access

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Abstract

Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), but the nature of cognitive changes varies considerably between individuals. According to the dual-syndrome hypothesis, one cluster of patients is characterized by deficits in executive function that may be related to fronto-striatal dysfunction. Other patients primarily show non-frontal cognitive impairments that progress rapidly to PD dementia (PDD). We provide a comprehensive review of event-related potential (ERP) studies to identify ERP measures substantiating the heterogeneity of cognitive impairment in PD. Our review revealed evidence for P3b and mismatch-negativity alterations in PDD, but not in non-demented PD, indicating that alterations of these ERPs constitute electrophysiological markers for PDD. In contrast, ERP correlates of executive functions, such as NoGo-P3, N2, and error(-related) negativity (Ne/ERN), appear to be attenuated in non-demented PD patients in a dopamine-dependent manner. Hence, ERP measures confirm and yield distinct electrophysiological markers for the heterogeneity of cognitive impairment in PD. We discuss limitations and open questions of the ERP approach and provide directions and predictions for future ERP research.

Type: Article
Title: Event-related potentials and cognition in Parkinson's disease: An integrative review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2016.08.003
Publisher version: http://doi.org/10.1016/j.neubiorev.2016.08.003
Language: English
Additional information: © 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
Keywords: Science & Technology, Life Sciences & Biomedicine, Behavioral Sciences, Neurosciences, Neurosciences & Neurology, Parkinson's disease, Cognition, Dementia, Executive function, Basal ganglia, Dopamine, Event-related potentials (ERPs), P3, P3a, P3b, MMN, NoGo-P3, N2, N-e/ERN, PROGRESSIVE SUPRANUCLEAR PALSY, MULTIPLE SYSTEM ATROPHY, VISUAL WORKING-MEMORY, AMYOTROPHIC-LATERAL-SCLEROSIS, AUDITORY SELECTIVE ATTENTION, MOVEMENT-RELATED POTENTIALS, FRONTAL-LOBE DYSFUNCTION, ERROR-RELATED NEGATIVITY, NON-CAUCASIAN PATIENTS, CHOICE-REACTION TASKS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/1511980
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