UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Challenges in detecting disease modification in Parkinson's disease clinical trials.

Athauda, D; Foltynie, T; (2016) Challenges in detecting disease modification in Parkinson's disease clinical trials. Parkinsonism Relat Disord , 32 pp. 1-11. 10.1016/j.parkreldis.2016.07.019. Green open access

[thumbnail of Foltynie_Challenges in detecting disease modification in Parkinson%E2%80%99s disease clinical trials.pdf]
Preview
Text
Foltynie_Challenges in detecting disease modification in Parkinson%E2%80%99s disease clinical trials.pdf

Download (1MB) | Preview

Abstract

Despite the wealth of encouraging data from numerous compounds that demonstrate "neuroprotection" in pre-clinical studies of Parkinson's disease, and despite numerous clinical trials, to date, no intervention has been demonstrated to able to modify the course of disease progression. While this "failure to translate" is likely due to numerous factors including our incomplete understanding of the pathogenic mechanisms underlying PD together with excessive reliance on data from the toxin-based animal models of PD, here we will discuss the "structural issues" pertaining to inadequate clinical trial design, selection of inappropriate endpoints and poor patient selection which are often not addressed following failed disease modification trials. Future directions to overcome these challenges such as reducing the heterogeneity of patient cohorts, identifying and utilising a pre-diagnostic population, embracing a personalised medicine approach and utilising novel trial designs may be required to ultimately fulfil the goal of conclusively demonstrating evidence of disease modification.

Type: Article
Title: Challenges in detecting disease modification in Parkinson's disease clinical trials.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.parkreldis.2016.07.019
Publisher version: http://dx.doi.org/10.1016/j.parkreldis.2016.07.019
Language: English
Additional information: © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1511918
Downloads since deposit
447Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item