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MicroRNA expression and its association with DNA repair in preimplantation embryos

Tulay, P; Sengupta, SB; (2016) MicroRNA expression and its association with DNA repair in preimplantation embryos. Journal of Reproduction and Development , 62 (3) pp. 225-234. 10.1262/jrd.2015-167. Green open access

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Abstract

Active DNA repair pathways are crucial for preserving genomic integrity and are likely among the complex mechanisms involved in the normal development of preimplantation embryos. MicroRNAs (miRNA), short non-coding RNAs, are key regulators of gene expression through the post-transcriptional and post-translational modification of mRNA. The association of miRNA expression with infertility or polycystic ovarian syndrome has been widely investigated; however, there are limited data regarding the importance of miRNA regulation in DNA repair during preimplantation embryo development. In this article, we review normal miRNA biogenesis and consequences of aberrant miRNA expression in the regulation of DNA repair in gametes and preimplantation embryos.

Type: Article
Title: MicroRNA expression and its association with DNA repair in preimplantation embryos
Open access status: An open access version is available from UCL Discovery
DOI: 10.1262/jrd.2015-167
Publisher version: http://doi.org/10.1262/jrd.2015-167
Language: English
Additional information: ©2016 by the Society for Reproduction and Development. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/4.0/>.
Keywords: Science & Technology, Life Sciences & Biomedicine, Agriculture, Dairy & Animal Science, Reproductive Biology, Agriculture, DNA repair, Embryo development, miRNA, miRNA biogenesis, mRNA expression, double-strand break, female reproductive-tract, short hairpin rnas, cell-cycle, damage response, gene-expression, down-regulation, messenger-rnas, posttranscriptional regulation, p53-inducible micrornas
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/1509436
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