Tulay, P;
Sengupta, SB;
(2016)
MicroRNA expression and its association with DNA repair in preimplantation embryos.
Journal of Reproduction and Development
, 62
(3)
pp. 225-234.
10.1262/jrd.2015-167.
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Abstract
Active DNA repair pathways are crucial for preserving genomic integrity and are likely among the complex mechanisms involved in the normal development of preimplantation embryos. MicroRNAs (miRNA), short non-coding RNAs, are key regulators of gene expression through the post-transcriptional and post-translational modification of mRNA. The association of miRNA expression with infertility or polycystic ovarian syndrome has been widely investigated; however, there are limited data regarding the importance of miRNA regulation in DNA repair during preimplantation embryo development. In this article, we review normal miRNA biogenesis and consequences of aberrant miRNA expression in the regulation of DNA repair in gametes and preimplantation embryos.
| Type: | Article |
|---|---|
| Title: | MicroRNA expression and its association with DNA repair in preimplantation embryos |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1262/jrd.2015-167 |
| Publisher version: | http://doi.org/10.1262/jrd.2015-167 |
| Language: | English |
| Additional information: | ©2016 by the Society for Reproduction and Development. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/4.0/>. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Agriculture, Dairy & Animal Science, Reproductive Biology, Agriculture, DNA repair, Embryo development, miRNA, miRNA biogenesis, mRNA expression, double-strand break, female reproductive-tract, short hairpin rnas, cell-cycle, damage response, gene-expression, down-regulation, messenger-rnas, posttranscriptional regulation, p53-inducible micrornas |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1509436 |
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