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Making nonwoven fibrous poly(epsilon-caprolactone) constructs for antimicrobial and tissue engineering applications by pressurized melt gyration

Xu, Z; Mahalingam, S; Basnett, P; Raimi-Abraham, B; Roy, I; Craig, D; Edirisinghe, M; (2016) Making nonwoven fibrous poly(epsilon-caprolactone) constructs for antimicrobial and tissue engineering applications by pressurized melt gyration. Macromolecular Materials and Engineering , 301 (8) pp. 922-934. 10.1002/mame.201600116. Green open access

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Abstract

A pressurized melt gyration process has been used for the first time to generate poly(ε-caprolactone) (PCL) fibers. Gyration speed, working pressure, and melt temperature are varied and these parameters influence the fiber diameter and the temperature enabled changing the surface morphology of the fibers. Two types of nonwoven PCL fiber constructs are prepared. First, Ag-doped PCL is studied for antibacterial activity using Gram-negative Escherichia coli and Pseudomonas aeruginosa microorganisms. The melt temperature used to make these constructs significantly influences antibacterial activity. Neat PCL nonwoven scaffolds are also prepared and their potential for application in muscular tissue engineering is studied with myoblast cells. Results show significant cell attachment, growth, and proliferation of cells on the scaffolds.

Type: Article
Title: Making nonwoven fibrous poly(epsilon-caprolactone) constructs for antimicrobial and tissue engineering applications by pressurized melt gyration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mame.201600116
Publisher version: http://dx.doi.org/10.1002/mame.201600116
Additional information: © 2016 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1509292
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