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The Use of Deep Brain Stimulation in Tourette Syndrome.

Akbarian-Tefaghi, L; Zrinzo, L; Foltynie, T; (2016) The Use of Deep Brain Stimulation in Tourette Syndrome. Brain Sciences , 6 (3) , Article 35. 10.3390/brainsci6030035. Green open access

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Abstract

Tourette syndrome (TS) is a childhood neurobehavioural disorder, characterised by the presence of motor and vocal tics, typically starting in childhood but persisting in around 20% of patients into adulthood. In those patients who do not respond to pharmacological or behavioural therapy, deep brain stimulation (DBS) may be a suitable option for potential symptom improvement. This manuscript attempts to summarise the outcomes of DBS at different targets, explore the possible mechanisms of action of DBS in TS, as well as the potential of adaptive DBS. There will also be a focus on the future challenges faced in designing optimized trials.

Type: Article
Title: The Use of Deep Brain Stimulation in Tourette Syndrome.
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/brainsci6030035
Publisher version: http://dx.doi.org/10.3390/brainsci6030035
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Keywords: DBS, TS deep brain stimulation, Tourette syndrome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1508900
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