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Hedgehog Signalling in the Embryonic Mouse Thymus

Barbarulo, A; Lau, C-I; Mengrelis, K; Ross, S; Solanki, A; Saldaña, JI; Crompton, T; (2016) Hedgehog Signalling in the Embryonic Mouse Thymus. Journal of Developmental Biology , 4 (3) , Article 22. 10.3390/jdb4030022. Green open access

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Abstract

T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

Type: Article
Title: Hedgehog Signalling in the Embryonic Mouse Thymus
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/jdb4030022
Publisher version: http://dx.doi.org/10.3390/jdb4030022
Language: English
Additional information: Copyright © 2016 by the Authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords: thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1508779
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