Barbarulo, A;
Lau, C-I;
Mengrelis, K;
Ross, S;
Solanki, A;
Saldaña, JI;
Crompton, T;
(2016)
Hedgehog Signalling in the Embryonic Mouse Thymus.
Journal of Developmental Biology
, 4
(3)
, Article 22. 10.3390/jdb4030022.
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Abstract
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.
| Type: | Article |
|---|---|
| Title: | Hedgehog Signalling in the Embryonic Mouse Thymus |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/jdb4030022 |
| Publisher version: | http://dx.doi.org/10.3390/jdb4030022 |
| Language: | English |
| Additional information: | Copyright © 2016 by the Authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508779 |
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