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Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms

Cohn, MD; Viding, E; McCrory, E; Pape, L; van den Brink, W; Doreleijers, TAH; Veltman, DJ; (2016) Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms. Psychiatry Research: Neuroimaging , 254 pp. 180-187. 10.1016/j.pscychresns.2016.07.003. Green open access

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Abstract

Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7 yr), characterized by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.

Type: Article
Title: Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pscychresns.2016.07.003
Publisher version: http://doi.org/10.1016/j.pscychresns.2016.07.003
Language: English
Additional information: © 2016 Elsevier Ireland Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neuroimaging, Psychiatry, Neurosciences & Neurology, Voxel-based morphometry, Brain structure, Conduct disorder, Callous-unemotional traits, Antisocial personality disorder, Limited prosocial emotions, Psychopathy, VOXEL-BASED MORPHOMETRY, DISRUPTIVE BEHAVIOR DISORDERS, BRAIN STRUCTURE ABNORMALITIES, PSYCHOPATHIC TRAITS, GRAY-MATTER, ANTISOCIAL-BEHAVIOR, AMYGDALA RESPONSE, PREFRONTAL CORTEX, NEURAL RESPONSES, EARLY-ONSET
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1508774
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