Banerjee, J;
Leung, TS;
Aladangady, N;
(2016)
Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow.
Vox Sanguinis
, 111
(4)
pp. 399-408.
10.1111/vox.12436.
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Abstract
BACKGROUND AND OBJECTIVE: The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age. MATERIALS AND METHODS: Preterm infants receiving blood transfusion were recruited to three groups: 1–7 (group 1; n = 20), 8–28 (group 2; n = 21) and ≥29 days of life (group 3; n = 18). Superior mesenteric artery (SMA) peak systolic (PSV) and diastolic velocities were measured 30–60 min pre- and post-transfusion using Doppler ultrasound scan. Splanchnic tissue haemoglobin index (sTHI), tissue oxygenation index (sTOI) and fractional tissue oxygen extraction (sFTOE) were measured from 15–20 min before to post-transfusion using near-infrared spectroscopy. RESULTS: The mean pretransfusion Hb in group 1, 2 and 3 was 11, 10 and 9 g/dl, respectively. The mean (SD) pretransfusion SMA PSV in group 1, 2 and 3 was 0·63 (0·32), 0·81 (0·33) and 0·97 (0·40) m/s, respectively, and this did not change significantly following transfusion. The mean (SD) pretransfusion sTOI in group 1, 2 and 3 was 36·7 (19·3), 44·6 (10·4) and 41·3 (10·4)%, respectively. The sTHI and sTOI increased (P < 0·01), and sFTOE decreased (P < 0·01) following transfusion in all groups. On multivariate analysis, changes in SMA PSV and sTOI following blood transfusion were not associated with PDA, feeding, pretransfusion Hb and mean blood pressure. CONCLUSION: Pretransfusion baseline splanchnic tissue oximetry and blood flow velocity varied with postnatal age. Blood transfusion improved intestinal tissue oxygenation without altering mesenteric blood flow velocity irrespective of postnatal ages.
| Type: | Article |
|---|---|
| Title: | Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/vox.12436 |
| Publisher version: | http://doi.org/10.1111/vox.12436 |
| Language: | English |
| Additional information: | Copyright © 2016 International Society of Blood Transfusion. This is the peer reviewed version of the following article: [Banerjee, J., Leung, T. S. and Aladangady, N. (2016), Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow. Vox Sanguinis, 111: 399–408. doi: 10.1111/vox.12436], which has been published in final form at http://doi.org/10.1111/vox.12436. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: | strategy; transfusion; transfusion – pediatrics; transfusion medicine (in general) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508558 |
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