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Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes

Babiker, T; Vedovato, N; Patel, K; Thomas, N; Finn, R; Mannikko, R; Chakera, AJ; ... Hattersley, AT; + view all (2016) Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia , 59 (6) pp. 1162-1166. 10.1007/s00125-016-3921-8. Green open access

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Abstract

The finding that patients with diabetes due to potassium channel mutations can transfer from insulin to sulfonylureas has revolutionised the management of patients with permanent neonatal diabetes. The extent to which the in vitro characteristics of the mutation can predict a successful transfer is not known. Our aim was to identify factors associated with successful transfer from insulin to sulfonylureas in patients with permanent neonatal diabetes due to mutations in KCNJ11 (which encodes the inwardly rectifying potassium channel Kir6.2).

Type: Article
Title: Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00125-016-3921-8
Publisher version: http://doi.org/10.1007/s00125-016-3921-8
Language: English
Additional information: Copyright © The Author(s) 2016. All rights reserved. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Endocrinology & Metabolism, ATP-sensitive potassium channel, Neonatal diabetes, Sulfonylurea receptor, KIR6.2 KCNJ11, Gluscose, Channel, ISLET
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1508506
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