Asquith, CRM;
Konstantinova, LS;
Laitinen, T;
Meli, ML;
Poso, A;
Rakitin, OA;
Hofmann-Lehmann, R;
(2016)
Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism.
ChemMedChem
, 11
(19)
pp. 2119-2126.
10.1002/cmdc.201600260.
Preview |
Text
Asquith_Evaluation of Substituted Evaluation of Substituted 123 Dithiazoles as Inhibitors of the Felinem.pdf Download (1MB) | Preview |
Abstract
A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
| Type: | Article |
|---|---|
| Title: | Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cmdc.201600260 |
| Publisher version: | http://dx.doi.org/10.1002/cmdc.201600260 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Asquith, CRM; Konstantinova, LS; Laitinen, T; Meli, ML; Poso, A; Rakitin, OA; Hofmann-Lehmann, R; (2016) Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism. ChemMedChem , 11 (19) pp. 2119-2126, which has been published in final form at http://dx.doi.org/10.1002/cmdc.201600260. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1508443 |
Archive Staff Only
 |
View Item |
