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Multimodality characterization of tissue microstructure with Magnetic Resonance and Optical Spectroscopy

Proverbio, A; (2016) Multimodality characterization of tissue microstructure with Magnetic Resonance and Optical Spectroscopy. Doctoral thesis , UCL (University College London). Green open access

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Abstract

Cancer introduces changes in the microstructure of tissues, and different modalities can characterise specific features. Diffusion Magnetic Resonance investigates the diffusion of water molecules within the microstructure, providing contrast to describe the confinement of water in the different cytological compartments. The migration of photons and their polarisation status in a medium is conditioned by scattering and absorption where scattering is related to the micro and nanostructure. For the first time, we demonstrate the use of two modalities to inform a combined model describing microstructural features non-invasively. Diffusion MR and Optical Spectroscopy provide complementary information about the tissue, and a common model can be used to provide bio-markers indicating presence and staging a cancerous lesion. Here, the common model is fitted to the signals from each modality to inform a collective characterisation of the microstructure. A proof of concept on a sample (oil in water emulsion) is proposed to test the approach, where time-domain optical spectra have been combined with diffusion NMR echoes. To demonstrate the first steps towards clinical feasibility, a diffusion MR imaging, based on Oscillating Gradient Spin Echoes (OGSE), has been implemented to investigate the smallest elements of the microstructure of fixed samples obtained from two human colorectal cell lines. Diffusion OGSE MR imaging was then combined with polarised light spectroscopy. The ultimate aim is to provide an implementable method for clinical practice, where the optical modality can be acquired in gastroscopy, independently from the MRI imaging. The target is to diagnose colorectal cancer and stage the grade non-invasively. Furthermore, this work provides a method that can be extended to other modalities with minor changes.

Type: Thesis (Doctoral)
Title: Multimodality characterization of tissue microstructure with Magnetic Resonance and Optical Spectroscopy
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Keywords: Multimodality, Diffusion MRI, Laser Scattering Spectroscopy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources
URI: https://discovery.ucl.ac.uk/id/eprint/1508376
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