UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Convective tissue movements play a major role in avian endocardial morphogenesis

Aleksandrova, A; Czirók, A; Szabó, A; Filla, MB; Hossain, MJ; Whelan, PF; Lansford, R; (2012) Convective tissue movements play a major role in avian endocardial morphogenesis. Developmental Biology , 363 (2) pp. 348-361. 10.1016/j.ydbio.2011.12.036. Green open access

[img]
Preview
Text
Szabo_nihms347848.pdf - Accepted version

Download (4MB) | Preview

Abstract

Endocardial cells play a critical role in cardiac development and function, forming the innermost layer of the early (tubular) heart, separated from the myocardium by extracellular matrix (ECM). However, knowledge is limited regarding the interactions of cardiac progenitors and surrounding ECM during dramatic tissue rearrangements and concomitant cellular repositioning events that underlie endocardial morphogenesis. By analyzing the movements of immunolabeled ECM components (fibronectin, fibrillin-2) and TIE1 positive endocardial progenitors in time-lapse recordings of quail embryonic development, we demonstrate that the transformation of the primary heart field within the anterior lateral plate mesoderm (LPM) into a tubular heart involves the precise co-movement of primordial endocardial cells with the surrounding ECM. Thus, the ECM of the tubular heart contains filaments that were associated with the anterior LPM at earlier developmental stages. Moreover, endocardial cells exhibit surprisingly little directed active motility, that is, sustained directed movements relative to the surrounding ECM microenvironment. These findings point to the importance of large-scale tissue movements that convect cells to the appropriate positions during cardiac organogenesis.

Type: Article
Title: Convective tissue movements play a major role in avian endocardial morphogenesis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ydbio.2011.12.036
Publisher version: http://dx.doi.org/10.1016/j.ydbio.2011.12.036
Language: English
Additional information: Copyright © 2012. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Endocardium; Embryo; Morphogenesis; Quail; Time-lapse; Cardiovascular; Imaging
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1508163
Downloads since deposit
90Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item