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Direct amidation of unprotected amino acids using B(OCH2CF3)3

Lanigan, RM; Karaluka, V; Sabatini, MT; Starkov, P; Badland, M; Boulton, L; Sheppard, TD; (2016) Direct amidation of unprotected amino acids using B(OCH2CF3)3. Chemical Communications , 52 (57) pp. 8846-8849. 10.1039/c6cc05147b. Green open access

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Abstract

A commercially available borate ester, B(OCH2CF3)3, can be used to achieve protecting-group free direct amidation of α-amino acids with a range of amines in cyclopentyl methyl ether. The method can be applied to the synthesis of medicinally relevant compounds, and can be scaled up to obtain gram quantities of products.

Type: Article
Title: Direct amidation of unprotected amino acids using B(OCH2CF3)3
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c6cc05147b
Publisher version: http://dx.doi.org/10.1039/c6cc05147b
Language: English
Additional information: Copyright © The Royal Society of Chemistry 2016. This article is made available under a Creative Commons Attribution 3.0 Unported license. Further details about CC BY licenses are available at http://creativecommons.org/licenses/by/3.0
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1507763
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