Wells, JA; Thomas, DL; Saga, T; Kershaw, J; Aoki, I; (2017) MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach. Journal of Cerebral Blood Flow & Metabolism , 37 (6) pp. 2076-2083. 10.1177/0271678X16660985.

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Abstract

The study and clinical assessment of brain disease is currently hindered by a lack of non-invasive methods for the detailed and accurate evaluation of cerebral vascular pathology. Angiography can detect aberrant flow in larger feeding arteries/arterioles but cannot resolve the micro-vascular network. Small vessels are a key site of vascular pathology that can lead to haemorrhage and infarction, which may in turn trigger or exacerbate neurodegenerative processes. In this study, we describe a method to investigate microvascular flow anisotropy using a hybrid arterial spin labelling and multi-direction diffusion-weighted MRI sequence. We present evidence that the technique is sensitive to the mean/predominant direction of microvascular flow in localised regions of the rat cortex. The data provide proof of principle for a novel and non-invasive imaging tool to investigate cerebral micro-vascular flow patterns in healthy and disease states.

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