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MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.

Wells, JA; Thomas, DL; Saga, T; Kershaw, J; Aoki, I; (2017) MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach. Journal of Cerebral Blood Flow & Metabolism , 37 (6) pp. 2076-2083. 10.1177/0271678X16660985. Green open access

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Abstract

The study and clinical assessment of brain disease is currently hindered by a lack of non-invasive methods for the detailed and accurate evaluation of cerebral vascular pathology. Angiography can detect aberrant flow in larger feeding arteries/arterioles but cannot resolve the micro-vascular network. Small vessels are a key site of vascular pathology that can lead to haemorrhage and infarction, which may in turn trigger or exacerbate neurodegenerative processes. In this study, we describe a method to investigate microvascular flow anisotropy using a hybrid arterial spin labelling and multi-direction diffusion-weighted MRI sequence. We present evidence that the technique is sensitive to the mean/predominant direction of microvascular flow in localised regions of the rat cortex. The data provide proof of principle for a novel and non-invasive imaging tool to investigate cerebral micro-vascular flow patterns in healthy and disease states.

Type: Article
Title: MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0271678X16660985
Publisher version: http://dx.doi.org/10.1177/0271678X16660985
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Arterial spin labelling, diffusion imaging, magnetic resonance imaging, micro-vascular, perfusion
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/1506370
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