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The importance of sustained attention in early Alzheimer's disease

Huntley, JD; Hampshire, A; Bor, D; Owen, AM; Howard, RJ; (2017) The importance of sustained attention in early Alzheimer's disease. International Journal of Geriatric Society , 32 (8) pp. 860-867. 10.1002/gps.4537. Green open access

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Abstract

INTRODUCTION: There is conflicting evidence regarding impairment of sustained attention in early Alzheimer's disease (AD). We examine whether sustained attention is impaired and predicts deficits in other cognitive domains in early AD. METHODS: Fifty-one patients with early AD (MMSE > 18) and 15 healthy elderly controls were recruited. The sustained attention to response task (SART) was used to assess sustained attention. A subset of 25 patients also performed tasks assessing general cognitive function (ADAS-Cog), episodic memory (Logical memory scale, Paired Associates Learning), executive function (verbal fluency, grammatical reasoning) and working memory (digit and spatial span). RESULTS: AD patients were significantly impaired on the SART compared to healthy controls (total error β = 19.75, p = 0.027). SART errors significantly correlated with MMSE score (Spearman's rho = -0.338, p = 0.015) and significantly predicted deficits in ADAS-Cog (β = 0.14, p = 0.004). DISCUSSIONS: Patients with early AD have significant deficits in sustained attention, as measured using the SART. This may impair performance on general cognitive testing, and therefore should be taken into account during clinical assessment, and everyday management of individuals with early AD.

Type: Article
Title: The importance of sustained attention in early Alzheimer's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/gps.4537
Publisher version: http://dx.doi.org/10.1002/gps.4537
Language: English
Additional information: This is the peer reviewed version of the following article: Huntley, JD; Hampshire, A; Bor, D; Owen, AM; Howard, RJ; (2016) The importance of sustained attention in early Alzheimer's disease, International Journal of Geriatric Society, which has been published in final form at: http://dx.doi.org/10.1002/gps.4537. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms).
Keywords: Alzheimer's disease, attention, cognition, neuropsychology
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/1506126
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