UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Granulomatosis with polyangiitis mimicking infective endocarditis in an adolescent male

Varnier, GC; Sebire, N; Christov, G; Eleftheriou, D; Brogan, PA; (2016) Granulomatosis with polyangiitis mimicking infective endocarditis in an adolescent male. Clinical Rheumatology , 35 (9) pp. 2369-2372. 10.1007/s10067-016-3337-3. Green open access

[thumbnail of Varnier et al Granulomatosis with polyangiitis mimicking infective endocarditis in an adolescent male.pdf]
Preview
Text
Varnier et al Granulomatosis with polyangiitis mimicking infective endocarditis in an adolescent male.pdf

Download (129kB) | Preview

Abstract

Granulomatosis with polyangiitis (GPA) is a rare but serious small vessel vasculitis with heterogeneous clinical presentation ranging from mainly localised disease with a chronic course, to a florid, acute small vessel vasculitic form characterised by severe pulmonary haemorrhage and/or rapidly progressive vasculitis or other severe systemic vasculitic manifestations. Cardiac involvement is, however, uncommon in the paediatric population. We report a case of a 16-year-old male who presented with peripheral gangrene and vegetation with unusual location on the supporting apparatus of the tricuspid valve, initially considered to have infective endocarditis but ultimately diagnosed with GPA. We provide an overview of the limited literature relating to cardiac involvement in GPA, and the diagnostic challenge relating to infective endocarditis in this context, especially focusing on the interpretation of the antineutrophil cytoplasmic antibody (ANCA) and the characteristic clinical features to identify in order to promptly recognise GPA, since timely diagnosis and treatment are essential for this potentially life-threatening condition.

Type: Article
Title: Granulomatosis with polyangiitis mimicking infective endocarditis in an adolescent male
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10067-016-3337-3
Publisher version: http://dx.doi.org/10.1007/s10067-016-3337-3
Language: English
Additional information: Copyright © International League of Associations for Rheumatology (ILAR) 2016. The final publication is available at Springer via http://dx.doi.org/10.1007/s10067-016-3337-3
Keywords: Adolescent ANCA-associated vasculitis, Granulomatosis with polyangiitis, Infective endocarditis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1504625
Downloads since deposit
157Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item