Calabresi, P;
Pisani, A;
Rothwell, J;
Ghiglieri, V;
Obeso, JA;
Picconi, B;
(2016)
Hyperkinetic disorders and loss of synaptic downscaling.
Nature Neuroscience
, 19
(7)
pp. 868-875.
10.1038/nn.4306.
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Abstract
Recent clinical and preclinical studies have shown that hyperkinetic disorders such as Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are all characterized by loss of the ability to reverse synaptic plasticity and an associated increase in the excitability of excitatory neuronal inputs to a range of cortical and subcortical brain areas. Moreover, these changes have been detected in humans with hyperkinetic disorders either via direct recordings from implanted deep brain electrodes or noninvasively using transcranial magnetic stimulation. Here we discuss the mechanisms underlying the loss of bidirectional plasticity and the possibility that future interventions could be devised to reverse these changes in patients with hyperkinetic movement disorders.
Type: | Article |
---|---|
Title: | Hyperkinetic disorders and loss of synaptic downscaling |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1038/nn.4306 |
Publisher version: | http://dx.doi.org/10.1038/nn.4306 |
Language: | English |
Additional information: | Copyright © 2016 Nature America, Inc. All rights reserved. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/1504427 |
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