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Hyperkinetic disorders and loss of synaptic downscaling

Calabresi, P; Pisani, A; Rothwell, J; Ghiglieri, V; Obeso, JA; Picconi, B; (2016) Hyperkinetic disorders and loss of synaptic downscaling. Nature Neuroscience , 19 (7) pp. 868-875. 10.1038/nn.4306. Green open access

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Abstract

Recent clinical and preclinical studies have shown that hyperkinetic disorders such as Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are all characterized by loss of the ability to reverse synaptic plasticity and an associated increase in the excitability of excitatory neuronal inputs to a range of cortical and subcortical brain areas. Moreover, these changes have been detected in humans with hyperkinetic disorders either via direct recordings from implanted deep brain electrodes or noninvasively using transcranial magnetic stimulation. Here we discuss the mechanisms underlying the loss of bidirectional plasticity and the possibility that future interventions could be devised to reverse these changes in patients with hyperkinetic movement disorders.

Type: Article
Title: Hyperkinetic disorders and loss of synaptic downscaling
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.4306
Publisher version: http://dx.doi.org/10.1038/nn.4306
Language: English
Additional information: Copyright © 2016 Nature America, Inc. All rights reserved.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1504427
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