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Pulse rate reactivity in childhood as a risk factor for adult hypertension: the 1970 British cohort study

Hamer, M; Kivimaki, M; Batty, GD; (2016) Pulse rate reactivity in childhood as a risk factor for adult hypertension: the 1970 British cohort study. Journal of Hypertension , 34 (9) pp. 1804-1807. 10.1097/HJH.0000000000001023. Green open access

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Abstract

Purpose: Cardiovascular reactivity to mental stress has been used as a tool to predict short-term hypertension risk in adults but the impact of cardiovascular reactivity in childhood on hypertension in adulthood is unknown. Using the 1970 British Cohort study, we examined the association between pulse rate reactivity in childhood and risk of hypertension in adulthood. / Methods: A total of 6507 participants (51.6% women) underwent clinical examination at 10 years of age that involved measurement of blood pressure, BMI, and pulse rate pre and postexamination. Hypertension was ascertained by self-reported doctor diagnosis 32 years later at age 42. / Results: On average, there was a reduction in pulse rate after the medical examination (-1.2 ± 8.2 bpm), although nearly a third of the sample recorded an increase in pulse rate of at least 3 bpm. A total of 488 (7.5%) study members developed hypertension at follow-up. After adjustment for a range of covariates, including resting blood pressure and BMI in childhood, a heightened pulse rate response to the examination (>=3 bpm) was associated with greater risk of hypertension in adulthood (odds ratio = 1.30, 95% confidence interval, 1.02, 1.67). The association persisted whether we modelled pulse rate as an absolute measure (postexamination) or a change score. / Conclusion: These observational data suggest that elevated childhood cardiovascular reactivity could increase risk for hypertension in adulthood.

Type: Article
Title: Pulse rate reactivity in childhood as a risk factor for adult hypertension: the 1970 British cohort study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/HJH.0000000000001023
Publisher version: http://dx.doi.org/10.1097/HJH.0000000000001023
Language: English
Additional information: This is a non-final version of an article published in final form in: Hamer, M; Kivimaki, M; Batty, GD; (2016) Pulse rate reactivity in childhood as a risk factor for adult hypertension: the 1970 British cohort study. Journal of Hypertension, 34 (9) pp. 1804-1807. doi:10.1097/HJH.0000000000001023.
Keywords: science & technology, life sciences & biomedicine, peripheral vascular disease, cardiovascular system & cardiology, birth cohort, epidemiology, psychophysiol pulse rate, stress, blood-pressure reactions, mental stress, follow-up, cardiovascular reactivity, stable hypertension, cortisol responses, birth cohort, healthy-men, life, women
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1504332
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